Memory B cells in PLWH displayed evidence of decreased germinal centre activity, homing capacity, and class-switching responses, with elevated PD-L1 expression, and decreased Tfh frequency. This was mirrored by enhanced extrafollicular activity, with dynamic alterations in activated double unfavorable and activated naïve B cells, which correlated with anti-RBD-titres in these...

  • November 11, 2022